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high copper intake downregulates intestinal absorption and upregulates biliary excretion, whereas deficiency states promote intestinal uptake and reduce biliary loss to conserve copper [89]

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Early trials suggested benefit, while several large modern randomized studies and a Cochrane analysis found little difference from placebo.* Prost-Tech Plus uses saw palmetto as part of a broader multi-ingredient formula, not as the only active.*

Apparent differences in graying patterns across populations and the potential link between premature graying and broader health issues highlight the need for a shift in research priorities